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In addition to ROS overproduction, the activation of MAPK and inactivation of phosphatidylinositol 3-kinase/Akt (a serine/threonine kinase that is also known as protein kinase B)/mammalian target of rapamycin (mTOR) are associated with both apoptosis and autophagy 6

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Nabarun Dasgupta, University of North Carolina Injury Prevention Research Center Some experts theorize that the high potency of fentanyl makes those who use drugs want to tweak or balance the effect with methamphetamine

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